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KMID : 0360419770130020019
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Korean Journal of Pharmacology
1977 Volume.13 No. 2 p.19 ~ p.34
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Blood pressure Response to Raised Intracranical Pressure in Rabbits and Cats
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Abstract
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1) The relationship of arterial blood pressure and heart rate with raised intracranial pressure induced by the epidural balloon method was investigated in anesthetized rabbits and cats.
2) In both animals marked increase of the blood pressure was observed when the intracranial prrssure became close to the blood pressure.
3) In both animals marked decrease in the blood prrssure and transitory marked decrease in the heart rate were observed, when the level of the intracranial pressure exceeded that of the blood pressure.
4) In reserpinized animals raised intracranial pressure produced decrease in the blood pressure and heart rate.
5) During raised intracranial pressure, the 6-hydroxydropamine-treated (by intracerebral administration) animals showed increase of the blood pressure less than control animals.
6) The depressor response to raised intracranial pressure in the reserpinized animals was reversed to the marked pressor one by the administration of norepinephrine into the lateral ventricle.
7) These results suggest that the pressor response to raised intracranial pressure is due to the increase of norepinephrine release resulted from local stimulation of the central sympathetic neurons by the raised intracranial pressure.
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